Cannabinoid System Discussion Paper

A cannabinoid system is a group of endogenous compounds that acts as an endocannabinoid neurotransmitter. The two primary cannabinoids in the body are Anandamide and 2-AG. These two compounds are not only found in the brain and nervous system but also throughout the body, including in blood vessels. Anandamide is primarily found in the central nervous system (CNS), a neurotransmitter that helps regulate mood, sleep cycles, and appetite. It also affects memory and learning. Neurons secrete Anandamide in brain areas that deal with muscle sensory input, and glands.2-AG is primarily found in the CNS. Still, it can also be found on nerve cells throughout the peripheral nervous system (PNS). 2-AG has been shown to regulate pain perception when administered via injection into rodent or primate brains or spinal cords. It also inhibits monoamine oxidase A (MAO-A), which breaks down monoamines such as dopamine and serotonin. In general, cannabinoids can be beneficial in several ways, which entails: the treatment of arthritis, cancer, Crohn’s disease, epilepsy, and multiple sclerosis, regulating functions such as appetite, mood, and sexual behavior, and also playing a pivotal role in how our bodies respond to pain due to inflammation as well as how our immune system works among others.

Cannabinoids are beneficial in treating arthritis, cancer, Crohn’s disease, epilepsy, and multiple sclerosis because they help to reduce inflammation in the body and inhibit the growth of tumors. Cannabinoid System Discussion Paper In the case of arthritis, cannabinoids are effective in reducing pain and stiffness associated with this condition. They also appear to reduce inflammation in the body by inhibiting the activity of certain enzymes that play a role in inflammatory responses (National Academies of Sciences, Engineering, and Medicine,2017). In addition to these anti-inflammatory actions, cannabinoids have also been shown to stimulate the production of new cartilage cells and promote cartilage repair. Cannabis has also been found to be an effective treatment for cancer patients suffering from nausea or pain due to chemotherapy treatments. It has been reported that marijuana can sometimes reduce tumor size and prolong survival rates. Additionally, it can help prevent nausea caused by radiation therapy and dyschezia (painful bowel movements) experienced by those undergoing colonoscopy procedures. In Crohn’s disease, an inflammation of the digestive tract caused by an improper immune response, oral administration of cannabinoids has shown promising results when used along with other traditional treatments such as immunosuppressants (drugs used for treating autoimmune diseases like Crohn’s). Furthermore, scientists have found evidence that suggests cannabis can be effective at slowing or preventing seizures associated with epilepsy and multiple sclerosis.

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Cannabinoids, including tetrahydrocannabinol (THC) and cannabidiol (CBD), are a group of compounds that have been studied for their effects on the brain. Recent research has shown that they can help regulate functions such as appetite, mood, and sexual behavior (For example, THC has been shown to increase appetite in human and animal studies(Atakan,2012). This effect is thought to result from the activation of CB1 receptors by THC in the brain. This can lead to increased food intake, which may benefit patients suffering from anorexia or bulimia nervosa.CBD has also shown anti-anxiety effects in animal models of anxiety. This effect may be due to its ability to activate CB2 receptors in the brain, which reduces levels of hormones such as cortisol. These two cannabinoids are not currently used for medical purposes because their effects are not yet well understood. However, further research into their potential benefits could lead us toward new treatments for conditions such as PTSD and other mental health issues currently treated with pharmaceuticals.

Cannabinoids are beneficial because they play a crucial role in how our bodies respond to pain due to inflammation and how our immune system works. Inflammation is a typical response to injury or infection. Inflammation is what happens when the body reacts to injury or infection. It is part of the immune response, and it helps you heal from injuries and infections so you can be healthier. It involves the body’s immune system and tissues damaged by the injury or infection (Bruni et al.,2018). Without inflammation, you would not be able to heal from injuries like cuts and wounds, nor would you be able to fight off infections like colds and flu. Cannabinoids can help with inflammation by reducing the number of immune cells in your body at any time. When we experience physical or emotional trauma, there are an increase in white blood cells called neutrophils (which help us fight off infections) and macrophages (which help us repair damaged tissue). Cannabinoids can reduce these numbers so that less inflammation occurs in the body. Cannabinoids also play a role in helping your immune system work properly by increasing the production of cytokines – proteins produced by cells that serve as messengers between different body parts – and decreasing the production of heat shock proteins (HSP), which helps keep inflammation under control. Therefore, If you have chronic pain, cannabinoids may help reduce inflammation in your body so that you can experience less pain.

References

National Academies of Sciences, Engineering, and Medicine. (2017). Therapeutic effects of cannabis and cannabinoids. In The health effects of cannabis and cannabinoids: The current state of evidence and recommendations for research. National Academies Press (US). https://www.ncbi.nlm.nih.gov/books/NBK425767/

Atakan, Z. (2012). Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic advances in psychopharmacology, 2(6), 241-254. https://journals.sagepub.com/doi/abs/10.1177/2045125312457586

Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid delivery systems for pain and inflammation treatment. Cannabinoid System Discussion Paper