Neuropsychiatric Comorbidities In Tuberous Essay
Neuropsychiatric Comorbidities In Tuberous Essay
Question:
Discuss About The Neuropsychiatric Comorbidities In Tuberous?
Answer:
Introduction
Neuropsychiatric comorbidities is the examination process of various coexisting illness in patients with mental disorders including the behaviors they exude (Hirschtritt et al, 2015). Various conditions such as tuberos sclerosis complex (TSC), management spectrum disorders (ASD), intellectual disability etc. are in most of the cases characterized in the patients in the process. TSC formed the center of focus of study for the neuropsychiatric comorbidities in the children. Neuropsychiatric Comorbidities In Tuberous Essay. In connection to that, TSC is a dominant autosomal condition that result from the transmutation of either TSC1 or TSC2 gene (De Vries et al, 2015). This study was conducted to determine the prevalence of neurological illness in children who have already been examined with tuberous sclerosis complex (TSC). The investigation focused on frequencies of some of the coexisting disorders in children with TS; the disorders include ASD, ADHD and OCD. Most of the previous researches show that in the higher percentage of patients with TS also display characteristics of the presence of other neurological symptoms disorders. Neuropsychiatric Comorbidities In Tuberous Essay.
Method Of Data Collection
Data is important in making a proof of the claim valid through full leverage of the so collected data (William et al, 2016). A sample is a proportion of a population of the subject of discussion (Gelman et al, 2014). A sample is always used to give the representation of the characteristics of the entire population (Davidson et al, 2013). In this study therefore, patients diagnosed with TS was the target and from the clinic records, a sample of 67 children patients’ records were examined making our sample size to be (67). Though the population of children in the clinic who were examined with TS was not disclosed, the suitable sample size is supposed to cover at least 30% of the entire population (Desu, 2012). Neuropsychiatric Comorbidities In Tuberous Essay.In our case healthcare, we were certain that sample size of 67 children was good enough to estimate the population’s characteristics and to obtain the statistic that will suitably represent the population parameter of the neuropsychiatric comorbidities in children with TS. There are various methods that can be employed in the collection of data from the participants which can either be primary or secondary data collection methods (Cleary et al, 2014). In this study, the type of data collected was secondary. As a result therefore, the data was obtained through the review of the patients’ records in the clinic for patients who were examined with TS. Frequency tables were used in representation of data using statistical package for social sciences (SPSS).
Behavioral and psychiatric comorbidity are common in tuberous sclerosis complex (TSC), but information regarding psychopharmacologic management is lacking. We reviewed clinical records of patients evaluated over a 20-month period at a large, quaternary referral center specializing in the comprehensive management of patients with TSC. Data were collected regarding psychiatric diagnoses, psychopharmacologic medications used to treat these disorders, and clinical response to treatment at follow-up. There were 113 encounters by 62 pediatric and adult patients with TSC, which were included in the present analysis. Behavioral and anxiety disorders were most prevalent, as were autism spectrum disorders and attention-deficit/hyperactivity disorder. Antipsychotics, antidepressants, and anticonvulsants with mood-stabilizing properties were the most often prescribed psychoactive medications and were associated with an overall improvement or stabilization of psychiatric symptoms 65% of the time. Psychiatric comorbidity, especially behavioral disorders, is very common among patients with TSC. Pharmacologic treatment can be very effective and should be considered for optimal disease management in affected individuals. Neuropsychiatric Comorbidities In Tuberous Essay.
Background/purpose: To clarify the relationship between neuroimaging findings, neuropsychiatric comorbidities, and epilepsy in patients with tuberous sclerosis complex (TSC) in Taiwan.
Methods: Medical records from 32 patients with TSC were retrospectively reviewed, including mutational analysis, neuroimaging findings, electroencephalogram findings, and neuropsychiatric comorbidities.
Results: Of these patients, six (18.75%) were diagnosed to have autism spectrum disorders (ASD), and 10 (31.25%) were diagnosed to have attention-deficit-hyperactivity disorder. In the latter patients, there were no differences in the regional distribution of tuber burden. In addition to a high prevalence of cystic-like tubers, tubers in insular and temporal areas were associated with ASD. Nonsense mutations in the TSC2 gene group had a correlation with autistic behavior. In 26 (81.25%) patients with a history of epilepsy, infantile spasms and partial seizures were the predominant type of epilepsy. Most of them developed seizures prior to age 1 year.
Conclusion: ASD is a common comorbidity in TSC. Cortical tubers in the temporal lobe and insular area were associated with ASD. The presence of cystic-like tubers on magnetic resonance imaging may also offer a structural marker for ASD in TSC.
Keywords: attention-deficit–hyperactivity disorder; autism spectrum disorder; seizure; tuberous sclerosis complex. Neuropsychiatric Comorbidities In Tuberous Essay.
