NURS 6521 week 1 Discussion: Pharmacokinetics and Pharmacodynamics

 Discussion – Main Post

For the last 5 years, I have worked in the Emergency Department at a very busy hospital in Miami, FL as well as a procedural department. The experience that I have chosen to reference for this post was during my time in Interventional Radiology. In this department, we provide services using all of the different modalities of imaging in order to complete biopsies, drainages, chest tubes, various line placements, and even catheter-directed infusions and embolization. The more common procedures center around hemodialysis catheters.

Hemodialysis patients are renal impaired and therefore metabolism and excretion are impacted. Renal disease affects tubular secretion and absorption, glomerular blood flow and filtration, and renal bioactivation and metabolism. (Gloe, 2016) During the procedure, patients are given conscious sedation using medications like Versed and Fentanyl. Renal drug excretion varies from patient to patient. Conditions such as chronic renal disease may cause profound alteration. (Rosenthal, & Burchum, 2021) For Renal patients, the doses administered should be adjusted significantly in order to avoid placing the patient in a hypotensive or prolonged hypoxic episode.

Typically, when a renal patient has any procedure ordered in our department. A baseline set of vital signs are obtained while the patient is being prepared in our pre-op area. This allows the nurse to assess the patient’s hemodynamic status before the procedure. During those procedures, two nurses should be present in order to constantly monitor and assess the patient during the procedure. Conscious sedation is administered initially at half the normal/usual dose in order to assess the patient’s reaction before the procedure. Once the medications are administered and the patient’s reactions are monitored and assessed, the procedure can begin. Once the procedure is completed, the patient is brought to our recovery area to continue to monitor the patient.

These processes were developed in order to constantly monitor and assure our patient’s safety. These processes were implemented after a traveling nurse administered an initial dose that was too much for the patient and a rapid response was called to recover the patient. Because this patient was a renal patient, the patient needed to be reversed and sent to dialysis for continued reversal.

 

References

Gloe, D. (2016). Medication Therapy Adjustments in Patients with Chronic Renal Failure. MEDSURG Nursing25(5), 325–328.

Rosenthal, L. D., Burchum, J. R. (2021). Lehne’s pharmacotherapeutics for advanced practice nurses and physician assistants (2nd ed.) St. Louis, MO: Elsevier.

 

response

I also work in a procedural department giving conscious sedation to patients for cardioversions and transesophageal echocardiograms (TEEs). I also provide care for patients post cardiac cath lab and interventional radiology (IR) procedures. All patients get sedation with versed and fentanyl in our department. Many of the patients I see have heart problems.  Along with cardiac issues, some patients also have diabetes and kidney disease. Chronic kidney disease causes profound alterations since the kidneys account for most drug excretions from the body (Rosenthal & Burchum, 2021).

Midazolam (Versed) is a benzodiazepine indicated for sedation and amnesia before or during a procedure. When sedating patients with this medication, special care in monitoring patient’s respiratory rate, airway, and cardiac function is required. Many of the doctors I work with seem to hurry when doing quick procedures, such as cardioversion and want the nurses to sedate them quickly. They sometimes verbally order 1-2mg of versed given about a minute apart. Versed is a medication that reaches its peak in the CNS in 3 to 5 minutes. Therefore, small doses of titration should be given 3 to 5 minutes apart for patient safety, allowing time between doses to take effect (RxList, 2019). As patient advocates, we have to keep patient safety a priority when administering medications, especially if we are depressing their CNS. The excretion of versed is reduced with older age, CHF, liver disease, or low cardiac output conditions (RxList, 2019). Having the reversal agent, flumazenil, readily available is imperative in situations where excess doses are given, and respiratory drive is compromised.

 

References:

Rosenthal, L. D., & Burchum, J. R. (2021). Lehne’s pharmacotherapeutics for advanced practice nurses and physician assistants (2nd ed.). St. Louis, MO: Elsevier.

RXList. (2019). Midazolam injection. Retrieved from https://www.rxlist.com/midazolam-injection-drug.htm#description

 

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